Absence of antimutagenicity of Cochlospermum regium (Mart. and Schr.) Pilger 1924 by micronucleus test in mice.
Braz J Biol
; 68(1): 155-9, 2008 Feb.
Article
in En
| MEDLINE
| ID: mdl-18470391
ABSTRACT
Cochlospermum regium (Mart. and Schr.) Pilger, popularly known as "algodãozinho do campo", is a medicinal plant that grows in the Cerrado of Brazil. This plant has been used in traditional medicine against various diseases such as leucorrhoea, gastritis and ulcers. It has also been effective in treating skin problems like pimples, boils and blotches. In the present study, the in vivo antimutagenicity of aqueous extract of C. regium was evaluated. The Micronucleus Test was performed in polychromatic erythrocytes from Swiss male mice treated with one of the four doses of extract of the plant (19, 38, 76 and 114 mg.kg(-1) body weight), administered by intraperitonial injection (i.p.) simultaneously with cyclophosphamide (24 mg.kg(-1) b.w.) or mitomycin C (4 mg.kg(-1) b.w.). The cytotoxicity was evaluated by polychromatic and normochromatic erythrocytes ratio (PCE/NCE). The results showed no significant reduction of the micronucleated polychromatic erythrocytes frequency (P > 0.05). In conclusion, the data indicate that C. regium roots aqueous extract, for the conditions used, did not exhibit the antimutagenic effect.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bone Marrow Cells
/
Micronucleus Tests
/
Antimutagenic Agents
/
Bixaceae
/
Erythrocytes
Limits:
Animals
Language:
En
Journal:
Braz J Biol
Journal subject:
BIOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Brazil