The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact.
J Smooth Muscle Res
; 44(1): 1-8, 2008 Feb.
Article
in En
| MEDLINE
| ID: mdl-18480593
ABSTRACT
In endothelium-intact rat aortic ring preparations pre-contracted with norepinephrine or KCl, NG-nitro L-arginine (L-NOARG, 0.1 mM) and 1H-[1,2,4] oxidiazolo [4,3-a] quinoxalin-1-one (ODQ, 10 microM) antagonized the reduction of the vascular tone induced by stevioside, but this antagonism did not occur when the experiment was performed with endothelium-denuded aortic rings. The data indicates that the vasodilatation produced by stevioside is dependent on nitric oxide synthase and guanylate cyclase activities when the endothelium is not damaged.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sweetening Agents
/
Vasodilation
/
Endothelium, Vascular
/
Nitric Oxide Synthase
/
Diterpenes, Kaurane
/
Glucosides
Limits:
Animals
Language:
En
Journal:
J Smooth Muscle Res
Journal subject:
FISIOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Brazil