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Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin.
Robinson, L R; Fitzgerald, N C; Doughty, D G; Dawes, N C; Berge, C A; Bissett, D L.
Affiliation
  • Robinson LR; The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH, USA.
Int J Cosmet Sci ; 27(3): 155-60, 2005 Jun.
Article in En | MEDLINE | ID: mdl-18492182
The palmitoyl pentapeptide palmitoyl-lysine-threonine-threonine-lysine-serine (pal-KTTKS) is a synthetic material that was designed as a topical agent to stimulate collagen production and thus provide a skin anti-wrinkle benefit. To determine if pal-KTTKS is effective, the clinical study reported here was conducted. Caucasian female subjects (n = 93, aged 35-55) participated in a 12-week, double-blind, placebo-controlled, split-face, left-right randomized clinical study assessing two topical products: moisturizer control product vs. the same moisturizer product containing 3 ppm pal-KTTKS. Pal-KTTKS was well tolerated by the skin and provided significant improvement vs. placebo control for reduction in wrinkles/fine lines by both quantitative technical and expert grader image analysis. In self-assessments, subjects also reported significant fine line/wrinkle improvements and noted directional effects for other facial improvement parameters.

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Int J Cosmet Sci Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Clinical_trials Language: En Journal: Int J Cosmet Sci Year: 2005 Document type: Article Affiliation country: United States Country of publication: United kingdom