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A weekly cisplatin-based induction regimen for extensive non-small cell lung cancer. A Southwest Oncology Group study.
Higano, C S; Crowley, J; Livingston, R B; Goodwin, J W; Barlogie, B; Stuckey, W J.
Affiliation
  • Higano CS; Puget Sound Oncology Consortium, Seattle, Washington.
Cancer ; 67(10): 2439-42, 1991 May 15.
Article in En | MEDLINE | ID: mdl-1849785
ABSTRACT
The purpose of this Phase II pilot study was to determine whether a dose-intensive regimen of weekly cisplatin combined with other active non-cross-resistant agents would improve the response rate and survival time of patients with extensive non-small cell lung cancer. Patients received cisplatin (50 mg/m2/wk) on days 1, 8, 15, 22, 36, 43, 50, and 57 combined with mitomycin C (8 mg/m2) on days 1 and 36, vinblastine (3 mg/m2) on days 8 and 43, and 5-fluorouracil (5-FU) (1 g/m2) by continuous infusion over 24 hours on days 15 and 50. Responding patients received consolidation therapy with cisplatin and etoposide (VP-16). Of 82 registered patients, 80 were eligible and 77 were evaluable for response. The overall response rate was 23% with 1 patient achieving a complete response (CR) and 17 patients achieving a partial response (PR). The median survival time was 4.6 months. The toxicity profile was not different from that described for standard-dose regimens. Although this regimen does not offer any benefit over standard-dose cisplatin regimens for patients with extensive non-small lung cancer, the weekly schedule permits a dose-intensive regimen with acceptable toxicity for tumors that may benefit from this approach.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Year: 1991 Document type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Year: 1991 Document type: Article