Evaluation of quality of life in patients with metastatic colorectal cancer treated with capecitabine.
Clin Colorectal Cancer
; 7(2): 126-33, 2008 Mar.
Article
in En
| MEDLINE
| ID: mdl-18501072
ABSTRACT
PURPOSE:
This study evaluated the effects of oral capecitabine on the quality of life (QOL) of Brazilian patients with metastatic colorectal cancer who received capecitabine (1000 or 1250 mg/m2 twice a day on days 1-14, every 3 weeks) in a prospective, multicenter, open-label, noncomparative study. PATIENTS ANDMETHODS:
Patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 and QLQ-CR38 questionnaires before cycle 1, at weeks 7 and 13, and at the end of treatment. In total, 1437 patients (mean age, 59.6 years [+/- 13.5 years]) were enrolled.RESULTS:
In women, statistically significant improvements were observed in 6 QLQ-C30 and 6 QLQ-CR38 domains (QLQ-C30 emotional function, nausea/ vomiting, pain, constipation, financial problems, and body image; QLQ-CR38 future perspective, micturition problems, defecation problems, stoma-related problems, weight loss and global health status). In men, statistically significant improvements were observed in 8 QLQ-C30 and 5 QLQ-CR38 domains (QLQ-C30 emotional function, social function, pain, insomnia, appetite loss, constipation, financial problems, and future perspective; QLQ-CR38 micturition problems, defecation problems, stoma-related problems, weight loss, and global health status). Statistically significant worsening of sexual function/enjoyment occurred in both sexes.CONCLUSION:
Overall, 59%-86% of patients maintained or improved QOL during capecitabine therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Colorectal Neoplasms
/
Deoxycytidine
/
Fluorouracil
/
Antimetabolites, Antineoplastic
Type of study:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Clin Colorectal Cancer
Journal subject:
GASTROENTEROLOGIA
/
NEOPLASIAS
Year:
2008
Document type:
Article
Affiliation country:
Brazil
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA