Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters.

Schickli, Jeanne H; Kaur, Jasmine; Macphail, Mia; Guzzetta, Jeanne M; Spaete, Richard R; Tang, Roderick S

Schickli, Jeanne H; Kaur, Jasmine; Macphail, Mia; Guzzetta, Jeanne M; Spaete, Richard R; Tang, Roderick S.

Affiliation

Schickli JH; Research Dept, MedImmune, Mountain View, CA 94043, USA. Schicklij@medimmune.com

Virol J ; 5: 69, 2008 Jun 03.

Article in En | MEDLINE | ID: mdl-18519001

Subject(s)

Metapneumovirus/growth & development; Mutation; Paramyxoviridae Infections/virology; Viral Proteins/genetics; Viral Proteins/metabolism; Virus Replication; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cricetinae; Gene Expression Regulation, Viral; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Humans; Mesocricetus; Metapneumovirus/genetics; Metapneumovirus/physiology; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Vero Cells; Viral Vaccines/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Virus Replication / Paramyxoviridae Infections / Metapneumovirus / Mutation Limits: Animals / Humans Language: En Journal: Virol J Journal subject: VIROLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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