Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.

Karunakaran, Senthil; Umapathy, Nagavedi S; Thangaraju, Muthusamy; Hatanaka, Takahiro; Itagaki, Shiro; Munn, David H; Prasad, Puttur D; Ganapathy, Vadivel

Karunakaran, Senthil; Umapathy, Nagavedi S; Thangaraju, Muthusamy; Hatanaka, Takahiro; Itagaki, Shiro; Munn, David H; Prasad, Puttur D; Ganapathy, Vadivel.

Affiliation

Karunakaran S; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.

Biochem J ; 414(3): 343-55, 2008 Sep 15.

Article in En | MEDLINE | ID: mdl-18522536

Subject(s)

Amino Acid Transport Systems, Neutral/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Tryptophan/analogs & derivatives; Amino Acid Transport Systems/metabolism; Amino Acid Transport Systems, Neutral/genetics; Amino Acid Transport Systems, Neutral/metabolism; Animals; Antineoplastic Agents/therapeutic use; Biological Transport, Active/drug effects; Cell Line; Cell Line, Tumor; Humans; Large Neutral Amino Acid-Transporter 1/genetics; Large Neutral Amino Acid-Transporter 1/metabolism; Mice; Oocytes/metabolism; Plasma Membrane Neurotransmitter Transport Proteins/metabolism; Tryptophan/metabolism; Tryptophan/pharmacology; Xenopus laevis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tryptophan / Amino Acid Transport Systems, Neutral / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Biochem J Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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