Cerebral meningioangiomatosis in a CD-1 mouse: a case report and comparison with humans and dogs.
Exp Toxicol Pathol
; 60(4-5): 247-51, 2008 Aug.
Article
in En
| MEDLINE
| ID: mdl-18524558
ABSTRACT
Meningioangiomatosis is a rare proliferative disorder of the central nervous system. Several cases have been described in humans, a few in dogs, one case in a cow and one in a horse; meningioangiomatosis has never been recorded in rodents. The pathogenesis of this condition remains obscure and it is uncertain whether it represents a neoplastic or malformative process. Meningioangiomatosis is usually characterized by a plaque-like leptomeningeal proliferation of mainly spindle-shaped cells and small blood vessels, extending along the Virchow-Robin spaces into the adjacent neural parenchyma. In this report, we presented a brain lesion displaying the histopathological key features of the meningioangiomatosis and involving the base of the cerebrum (fronto-basal area) and the brainstem, found in a male CD-1 mouse. The histopathological and immunohistochemical results are discussed, and compared with those previously reported in other cases of meningioangiomatosis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Diseases
/
Angiomatosis
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Exp Toxicol Pathol
Journal subject:
PATOLOGIA
/
TOXICOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
France
Publication country:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY