[The study on the preparation and spectroscopic properties of hydroxypropyl-beta-cyclodextrin/glipizide inclusion complex].
Guang Pu Xue Yu Guang Pu Fen Xi
; 28(3): 711-4, 2008 Mar.
Article
in Zh
| MEDLINE
| ID: mdl-18536450
ABSTRACT
The interaction of glipizide and hydroxypropyl-pcyclodextrin was investigated in the present paper. The stability constant and molar ratio of glipizide and hydroxypropyl-beta-cyclodextrin was calculated from the phase soluility diagram. The solid state inclusion complex of hydroxypropyl-beta-cyclodextrin/glipizide prepared by neutralization method was characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). It was found that the phase solubility diagram of the HP-beta-CD solution showed a typical AL-type, suggesting the formation of a soluble complex of 1 1 molar ratio, and the stability constant was 359 L x mol(-1) at 25 degrees C. The spectra of IR, thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the glipizide and hydroxypropyl-beta-cyclodextrin/glipizide physical mixture, and indicated that hydroxypropyl-beta-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic. The experiment of solubility of inclusion complex indicated that the solubility of inclusion complex increased 25-fold.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
X-Ray Diffraction
/
Calorimetry, Differential Scanning
/
Spectroscopy, Fourier Transform Infrared
/
Beta-Cyclodextrins
/
Glipizide
Language:
Zh
Journal:
Guang Pu Xue Yu Guang Pu Fen Xi
Year:
2008
Document type:
Article
Affiliation country:
China