Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.

Arbour, Nicole; Vanderluit, Jacqueline L; Le Grand, J Nicole; Jahani-Asl, Arezu; Ruzhynsky, Vladimir A; Cheung, Eric C C; Kelly, Melissa A; MacKenzie, Alexander E; Park, David S; Opferman, Joseph T; Slack, Ruth S

Arbour, Nicole; Vanderluit, Jacqueline L; Le Grand, J Nicole; Jahani-Asl, Arezu; Ruzhynsky, Vladimir A; Cheung, Eric C C; Kelly, Melissa A; MacKenzie, Alexander E; Park, David S; Opferman, Joseph T; Slack, Ruth S.

Affiliation

Arbour N; Department of Biochemistry, Microbiology, and Immunology, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.

J Neurosci ; 28(24): 6068-78, 2008 Jun 11.

Article in En | MEDLINE | ID: mdl-18550749

Subject(s)

Apoptosis/physiology; Central Nervous System/embryology; DNA Damage/physiology; Gene Expression Regulation, Developmental/physiology; Neurons/physiology; Proto-Oncogene Proteins c-bcl-2/physiology; Age Factors; Animals; Apoptosis/genetics; Caspase 3/metabolism; Cell Differentiation; Cell Movement/genetics; Cell Movement/physiology; Cell Proliferation; Cells, Cultured; Central Nervous System/cytology; DNA Damage/genetics; Embryo, Mammalian; Gene Expression Regulation, Developmental/genetics; Green Fluorescent Proteins/metabolism; Mice; Mice, Transgenic; Mutation/genetics; Myeloid Cell Leukemia Sequence 1 Protein; Nerve Tissue Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/genetics; Stem Cells/physiology; Transfection/methods; Tubulin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Central Nervous System / Apoptosis / Gene Expression Regulation, Developmental / Proto-Oncogene Proteins c-bcl-2 / Neurons Limits: Animals Language: En Journal: J Neurosci Year: 2008 Document type: Article Country of publication: United States

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