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Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors.
Lorusso, Patricia; Heath, Elisabeth I; McGreivy, Jesse; Sun, Yu-Nien; Melara, Rebeca; Yan, Lucy; Malburg, Lisa; Ingram, Megan; Wiezorek, Jeffrey; Chen, Li; Pilat, Mary Jo.
Affiliation
  • Lorusso P; Karmanos Cancer Institute, 4100 John R, 4 HWCRC, Detroit, MI, 48201, USA. lorussop@karmanos.org
Invest New Drugs ; 26(5): 455-62, 2008 Oct.
Article in En | MEDLINE | ID: mdl-18574557
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Niacinamide / Cytochrome P-450 CYP3A Inhibitors / Indoles / Ketoconazole / Neoplasms Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2008 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Niacinamide / Cytochrome P-450 CYP3A Inhibitors / Indoles / Ketoconazole / Neoplasms Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2008 Document type: Article Affiliation country: United States