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Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Cox, Christopher D; Coleman, Paul J; Breslin, Michael J; Whitman, David B; Garbaccio, Robert M; Fraley, Mark E; Buser, Carolyn A; Walsh, Eileen S; Hamilton, Kelly; Schaber, Michael D; Lobell, Robert B; Tao, Weikang; Davide, Joseph P; Diehl, Ronald E; Abrams, Marc T; South, Vicki J; Huber, Hans E; Torrent, Maricel; Prueksaritanont, Thomayant; Li, Chunze; Slaughter, Donald E; Mahan, Elizabeth; Fernandez-Metzler, Carmen; Yan, Youwei; Kuo, Lawrence C; Kohl, Nancy E; Hartman, George D.
Affiliation
  • Cox CD; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486, USA. chris_cox@merck.com
J Med Chem ; 51(14): 4239-52, 2008 Jul 24.
Article in En | MEDLINE | ID: mdl-18578472
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyrroles / Kinesins / Taxoids / Enzyme Inhibitors / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyrroles / Kinesins / Taxoids / Enzyme Inhibitors / Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States