Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.

Kuo, Chih-Jung; Shie, Jiun-Jie; Fang, Jim-Min; Yen, Guei-Rung; Hsu, John T-A; Liu, Hun-Ge; Tseng, Sung-Nain; Chang, Shih-Cheng; Lee, Ching-Yin; Shih, Shin-Ru; Liang, Po-Huang

Kuo, Chih-Jung; Shie, Jiun-Jie; Fang, Jim-Min; Yen, Guei-Rung; Hsu, John T-A; Liu, Hun-Ge; Tseng, Sung-Nain; Chang, Shih-Cheng; Lee, Ching-Yin; Shih, Shin-Ru; Liang, Po-Huang.

Affiliation

Kuo CJ; Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Taipei 11529, Taiwan.

Bioorg Med Chem ; 16(15): 7388-98, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18583140

Subject(s)

Antiviral Agents/chemistry; Antiviral Agents/pharmacology; Enterovirus A, Human/drug effects; Enterovirus A, Human/enzymology; Viral Proteins/antagonists & inhibitors; 3C Viral Proteases; Amino Acid Sequence; Binding Sites; Cell Line, Tumor; Computer Simulation; Cysteine Endopeptidases/chemistry; Drug Design; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Substrate Specificity; Viral Proteins/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Viral Proteins / Enterovirus A, Human Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

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