Metyrapone prevents cortisone-induced preadipocyte differentiation by depleting luminal NADPH of the endoplasmic reticulum.

Marcolongo, Paola; Senesi, Silvia; Gava, Barbara; Fulceri, Rosella; Sorrentino, Vincenzo; Margittai, Eva; Lizák, Beáta; Csala, Miklós; Bánhegyi, Gábor; Benedetti, Angelo

Marcolongo, Paola; Senesi, Silvia; Gava, Barbara; Fulceri, Rosella; Sorrentino, Vincenzo; Margittai, Eva; Lizák, Beáta; Csala, Miklós; Bánhegyi, Gábor; Benedetti, Angelo.

Affiliation

Marcolongo P; Dipartimento di Fisiopatologia, Medicina Sperimentale e Sanità Pubblica, Università di Siena, Siena, Italy.

Biochem Pharmacol ; 76(3): 382-90, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18599022

Subject(s)

Adipocytes/drug effects; Cell Differentiation/drug effects; Cortisone/pharmacology; Endoplasmic Reticulum/drug effects; Enzyme Inhibitors/pharmacology; Metyrapone/pharmacology; NADP/antagonists & inhibitors; 11-beta-Hydroxysteroid Dehydrogenase Type 1/biosynthesis; 3T3-L1 Cells; Adipocytes/cytology; Adipocytes/enzymology; Animals; Endoplasmic Reticulum/enzymology; Fibroblasts/cytology; Fibroblasts/drug effects; Fibroblasts/enzymology; Humans; Male; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/drug effects; Mesenchymal Stem Cells/enzymology; Mice; Microsomes, Liver/drug effects; Microsomes, Liver/enzymology; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cortisone / Cell Differentiation / Adipocytes / Endoplasmic Reticulum / Enzyme Inhibitors / Metyrapone / NADP Limits: Animals / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2008 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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