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Dependence of antibody-mediated presentation of antigen on FcRn.
Qiao, Shuo-Wang; Kobayashi, Kanna; Johansen, Finn-Eirik; Sollid, Ludvig M; Andersen, Jan Terje; Milford, Edgar; Roopenian, Derry C; Lencer, Wayne I; Blumberg, Richard S.
Affiliation
  • Qiao SW; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Proc Natl Acad Sci U S A ; 105(27): 9337-42, 2008 Jul 08.
Article in En | MEDLINE | ID: mdl-18599440
ABSTRACT
The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Fc / Histocompatibility Antigens Class I / Antigen Presentation Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2008 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Receptors, Fc / Histocompatibility Antigens Class I / Antigen Presentation Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2008 Document type: Article Affiliation country: United States