Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells.

Tu, Wu-Chun; Wu, Chun-Chi; Hsieh, Hui-Lien; Chen, Chiu-Yuan; Hsu, Shih-Lan

Tu, Wu-Chun; Wu, Chun-Chi; Hsieh, Hui-Lien; Chen, Chiu-Yuan; Hsu, Shih-Lan.

Affiliation

Tu WC; Department of Entomology, National Chung Hsing University, Taichung, Taiwan, ROC.

Toxicon ; 52(2): 318-29, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18602939

Subject(s)

Apoptosis/drug effects; Bee Venoms/toxicity; Bees/physiology; Calcium/metabolism; Caspases/metabolism; Melanoma/drug therapy; Animals; Calcium/pharmacology; Cell Line, Tumor; Cell Survival/drug effects; Cytosol/chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Enzyme Inhibitors/pharmacology; Extracellular Signal-Regulated MAP Kinases/biosynthesis; Fibroblasts/drug effects; Fibroblasts/metabolism; Fibroblasts/pathology; Formazans/metabolism; Humans; MAP Kinase Kinase 4/antagonists & inhibitors; MAP Kinase Kinase 4/biosynthesis; Melanoma/metabolism; Melanoma/pathology; Melitten/pharmacology; Membrane Potential, Mitochondrial/drug effects; Ouabain/pharmacology; Reactive Oxygen Species/metabolism; Tetrazolium Salts/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bee Venoms / Bees / Calcium / Apoptosis / Caspases / Melanoma Limits: Animals / Humans Language: En Journal: Toxicon Year: 2008 Document type: Article Country of publication: United kingdom

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