Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP).

Haffner, Curt D; Diaz, Caroline J; Miller, Aaron B; Reid, Robert A; Madauss, Kevin P; Hassell, Annie; Hanlon, Mary H; Porter, David J T; Becherer, J David; Carter, Luke H

Haffner, Curt D; Diaz, Caroline J; Miller, Aaron B; Reid, Robert A; Madauss, Kevin P; Hassell, Annie; Hanlon, Mary H; Porter, David J T; Becherer, J David; Carter, Luke H.

Affiliation

Haffner CD; Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, 5 Moore Drive, Research Triangle Park, NC 27709, USA. curt.d.haffner@gsk.com

Bioorg Med Chem Lett ; 18(15): 4360-3, 2008 Aug 01.

Article in En | MEDLINE | ID: mdl-18606544

Subject(s)

Pyridones/chemical synthesis; Pyridones/pharmacology; Pyrrolidines/chemical synthesis; Pyrrolidines/pharmacology; Serine Endopeptidases/drug effects; Serine Proteinase Inhibitors/chemical synthesis; Serine Proteinase Inhibitors/pharmacology; Brain/drug effects; Brain/metabolism; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Drug Design; Humans; Molecular Conformation; Molecular Structure; Prolyl Oligopeptidases; Pyridones/blood; Pyridones/chemistry; Pyrrolidines/blood; Pyrrolidines/chemistry; Serine Proteinase Inhibitors/blood; Serine Proteinase Inhibitors/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Pyrrolidines / Serine Endopeptidases / Serine Proteinase Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States

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