Demyelinating myelin oligodendrocyte glycoprotein-specific autoantibody response is focused on one dominant conformational epitope region in rodents.

Breithaupt, Constanze; Schäfer, Beatrix; Pellkofer, Hannah; Huber, Robert; Linington, Christopher; Jacob, Uwe

Breithaupt, Constanze; Schäfer, Beatrix; Pellkofer, Hannah; Huber, Robert; Linington, Christopher; Jacob, Uwe.

Affiliation

Breithaupt C; Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Emeritusgruppe Huber, Martinsried, Germany. constanze.breithaupt@biochemtech.uni-halle.de

J Immunol ; 181(2): 1255-63, 2008 Jul 15.

Article in En | MEDLINE | ID: mdl-18606679

Subject(s)

Autoantibodies/immunology; Epitopes/immunology; Myelin-Associated Glycoprotein/chemistry; Myelin-Associated Glycoprotein/immunology; Amino Acid Sequence; Animals; Antibody Specificity; Demyelinating Autoimmune Diseases, CNS/immunology; Epitopes/chemistry; Female; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins/chemistry; Mutant Proteins/immunology; Myelin Proteins; Myelin-Associated Glycoprotein/metabolism; Myelin-Oligodendrocyte Glycoprotein; Point Mutation; Protein Conformation; Rats; Sequence Alignment

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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Myelin-Associated Glycoprotein / Epitopes Limits: Animals / Female / Humans Language: En Journal: J Immunol Year: 2008 Document type: Article Affiliation country: Germany

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