Investigation into the mechanism by which cyclodextrins influence transdermal drug delivery.

Kear, Clifford L; Yang, Jing; Godwin, Donald A; Felton, Linda A

Kear, Clifford L; Yang, Jing; Godwin, Donald A; Felton, Linda A.

Affiliation

Kear CL; College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA.

Drug Dev Ind Pharm ; 34(7): 692-7, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18608463

Subject(s)

Excipients/pharmacology; Glucocorticoids/pharmacokinetics; Skin Absorption; beta-Cyclodextrins/pharmacology; 2-Hydroxypropyl-beta-cyclodextrin; Administration, Cutaneous; Animals; Glucocorticoids/chemistry; Hydrocortisone/chemistry; Hydrocortisone/pharmacokinetics; Mice; Mice, Hairless; Permeability; Phase Transition; Skin/drug effects; Skin/metabolism; Solubility; Thermodynamics; Time Factors; Transition Temperature; Triamcinolone/chemistry; Triamcinolone/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Absorption / Beta-Cyclodextrins / Excipients / Glucocorticoids Type of study: Prognostic_studies Limits: Animals Language: En Journal: Drug Dev Ind Pharm Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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