A key transcription cofactor on the nascent sex chromosomes of European tree frogs (Hyla arborea).
Genetics
; 179(3): 1721-3, 2008 Jul.
Article
in En
| MEDLINE
| ID: mdl-18622030
ABSTRACT
We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) within their glutamine-rich central part. These changes have the potential to affect the conformation of the Mediator complex and to activate genes in a sex-specific way and might thus represent the first steps toward the acquisition of a male-specific function. Alternatively, they might result from an ancestral neutral polymorphism, with different alleles picked by chance on the X and Y chromosomes when MED15 was trapped in the nonrecombining segment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ranidae
/
Sex Chromosomes
/
Transcription Factors
Limits:
Animals
Country/Region as subject:
Europa
Language:
En
Journal:
Genetics
Year:
2008
Document type:
Article
Affiliation country:
Switzerland