Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib.

Liu, Feng-Ting; Agrawal, Samir G; Movasaghi, Zanyar; Wyatt, Peter B; Rehman, Ihtesham U; Gribben, John G; Newland, Adrian C; Jia, Li

Liu, Feng-Ting; Agrawal, Samir G; Movasaghi, Zanyar; Wyatt, Peter B; Rehman, Ihtesham U; Gribben, John G; Newland, Adrian C; Jia, Li.

Affiliation

Liu FT; Centre for Haematology, Institute of Cell and Molecular Science, Queen Mary University of London, London, United Kingdom.

Blood ; 112(9): 3835-46, 2008 Nov 01.

Article in En | MEDLINE | ID: mdl-18633129

Subject(s)

Antineoplastic Agents/antagonists & inhibitors; Boronic Acids/antagonists & inhibitors; Flavonoids/adverse effects; Pyrazines/antagonists & inhibitors; Apoptosis/drug effects; Boric Acids/pharmacology; Bortezomib; Cell Line, Transformed; Cell Line, Tumor; Cytochromes c/metabolism; Diet/adverse effects; Free Radical Scavengers/adverse effects; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell/diet therapy; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell/pathology; Lymphoma, B-Cell/diet therapy; Lymphoma, B-Cell/drug therapy; Lymphoma, B-Cell/pathology; Multiple Myeloma/diet therapy; Multiple Myeloma/drug therapy; Multiple Myeloma/pathology; Protease Inhibitors/pharmacology; Quercetin/adverse effects; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Flavonoids / Boronic Acids / Antineoplastic Agents Limits: Humans Language: En Journal: Blood Year: 2008 Document type: Article Affiliation country: United kingdom Country of publication: United States

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