No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.
J Rheumatol
; 35(9): 1817-9, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18634151
ABSTRACT
OBJECTIVE:
The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.METHODS:
We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets.RESULTS:
No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study.CONCLUSION:
The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scleroderma, Systemic
/
Leukocyte Common Antigens
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
J Rheumatol
Year:
2008
Document type:
Article
Affiliation country:
Germany