Transplant-associated Ochroconis gallopava infections.
Transpl Infect Dis
; 10(6): 442-8, 2008 Dec.
Article
in En
| MEDLINE
| ID: mdl-18651872
ABSTRACT
BACKGROUND:
Ochroconis gallopava is a neurotropic dematiaceous mold that causes respiratory and central nervous system (CNS) infection in domestic poultry and in immunocompromised patients. We recently treated 3 solid organ transplant (SOT) recipients for pulmonary Ochroconis infections with successful outcome, prompting us to review the literature on this unique pathogen.METHODS:
We reviewed all published cases of O. gallopava infections in SOT recipients and analyzed the impact of CNS infection on the outcome.RESULTS:
In addition to the 3 new cases reported here, 9 published cases of Ochroconis infection were analyzed. The disease involved the lungs only in 5/12 (42%) of patients, brain in 6/12 (50%) patients, and lung and skin in 1 patient. Survival was significantly reduced with brain infection (33% vs. 100%; P<0.03; Fisher's exact test).CONCLUSIONS:
O. gallopava may infect SOT recipients with a particular tropism for the CNS. Early recognition of O. gallopava pulmonary infection is important, as the prognosis is excellent before dissemination to the brain.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia
/
Ascomycota
/
Brain Diseases
/
Organ Transplantation
/
Central Nervous System Fungal Infections
/
Mycoses
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
/
Asia
Language:
En
Journal:
Transpl Infect Dis
Journal subject:
TRANSPLANTE
Year:
2008
Document type:
Article
Affiliation country:
United States