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CYP2C8- and CYP3A-mediated C-demethylation of (3-{[(4-tert-butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid (CP-533,536), an EP2 receptor-selective prostaglandin E2 agonist: characterization of metabolites by high-resolution liquid chromatography-tandem mass spectrometry and liquid chromatography/mass spectrometry-nuclear magnetic resonance.
Prakash, Chandra; Wang, Weiwei; O'Connell, Thomas; Johnson, Kim A.
Affiliation
  • Prakash C; Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut, USA. chandra.prakash@biogenidec.com
Drug Metab Dispos ; 36(10): 2093-103, 2008 Oct.
Article in En | MEDLINE | ID: mdl-18653741
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Aryl Hydrocarbon Hydroxylases / Dinoprostone / Chromatography, High Pressure Liquid / Receptors, Prostaglandin E / Cytochrome P-450 Enzyme System Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Aryl Hydrocarbon Hydroxylases / Dinoprostone / Chromatography, High Pressure Liquid / Receptors, Prostaglandin E / Cytochrome P-450 Enzyme System Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States