Co-inheritance of haemoglobin A2' and beta-thalassaemia in cis.
Int J Lab Hematol
; 30(4): 334-8, 2008 Aug.
Article
in En
| MEDLINE
| ID: mdl-18665832
ABSTRACT
HbA2' is a haematologically silent delta chain variant that elutes in the S-region on high performance liquid chromatography. The major clinical significance of HbA2' is that failure to detect it might lead to failure to recognize beta-thalassaemia minor. Co-inheritance of HbA2' and beta-thalassaemia in cis has been described only once in a family from Suriname. We describe a new case of co-inheritance in cis of HbA2' and beta-thalassaemia in a family from Ghanaian origin with a HbA2' of more than 3%. Molecular investigation revealed the same mutations as in the family from Suriname, suggesting a common origin of both families.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hemoglobin A2
/
Beta-Thalassemia
Limits:
Adult
/
Child, preschool
/
Humans
/
Infant
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
Int J Lab Hematol
Journal subject:
HEMATOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
Belgium