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Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.
Zubenko, G S; Brenner, R P; Teply, I.
Affiliation
  • Zubenko GS; Department of Psychiatry, University of Pittsburgh School of Medicine 15213.
Stroke ; 22(8): 997-1003, 1991 Aug.
Article in En | MEDLINE | ID: mdl-1866768
We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Cerebrovascular Disorders / Alzheimer Disease / Membrane Fluidity Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans Language: En Journal: Stroke Year: 1991 Document type: Article Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Cerebrovascular Disorders / Alzheimer Disease / Membrane Fluidity Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans Language: En Journal: Stroke Year: 1991 Document type: Article Country of publication: United States