Determination of the persistence of pharmaceuticals in biosolids using liquid-chromatography tandem mass spectrometry.
Chemosphere
; 73(4): 511-8, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18674794
ABSTRACT
Sludge generated in waste water treatment process can be a major sink for some pharmaceutical and personal care products (PPCPs). The land application of sewage sludge (in the form of biosolids in the United States) can therefore potentially introduce PPCPs into the environment. After treatment, biosolids are often subjected to a storage period before land application. However, little information is available with regard to the fate of PPCPs in biosolids during the storage. In this work, the persistence of seven pharmaceuticals and one antibacterial was evaluated using ultrasonic extraction and liquid-chromatography tandem mass spectrometry (LC-MS/MS). The impacts of aeration and sunlight exposure were investigated. During the experiment, no elimination was observed for carbamazepine, triclosan, and ciprofloxacin while elimination was found for tetracycline, doxycycline, clindamycin, erythromycin, and clarithromycin. Using an availability-adjusted kinetic model, the 50% dissipation time was 37 to >77d for tetracycline, 53 to >77d for doxycycline, 1.0-1.6d for clindamycin, 1.1-1.9d for clarithromycin, and 7.0-17d for erythromycin. Those compounds were found more persistent under anaerobic conditions than aerobic condition with a longer 50% dissipation time by a factor of 1.5-2. However, minor impact was observed from sunlight irradiation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sewage
/
Pharmaceutical Preparations
/
Chromatography, Liquid
/
Tandem Mass Spectrometry
Type of study:
Prognostic_studies
Language:
En
Journal:
Chemosphere
Year:
2008
Document type:
Article
Affiliation country:
United States