Prevention of exercise-induced asthma by a fixed combination of disodium cromoglycate plus reproterol compared with montelukast in young patients.
Arzneimittelforschung
; 58(6): 303-9, 2008.
Article
in En
| MEDLINE
| ID: mdl-18677973
ABSTRACT
BACKGROUND:
The leukotriene inhibitor montelukast has been recommended against exercise-induced asthma (EIA), however, single-dose agents might be favourable in several aspects.OBJECTIVE:
To compare the protective effects against EIA of a single inhalation of the combination disodium cromoglycate (DSCG, CAS 16110-51-3) and reproterol (REP, CAS 54063-54-6) with 3 days oral treatment of montelukast (MON, CAS 158966-92-8).METHODS:
Open-label, cross-over, single-centre trial. Twenty-four 6 to 18-year-old children and adolescents, with reversible and stable airway obstruction, baseline FEV1 > or = 70%, predicted and proven EIA (i.e. a maximum decrease of FEV1 by > or = 20% compared with baseline) were treated with MON, orally for 3 days in the evening, or one single inhalation of DSCG/REP 20 min before the exercise challenge. The treatment sequence was randomised. The exercise test on a treadmill was performed under standardised conditions.RESULTS:
24 patients completed both periods. Both treatments clearly provided protection against EIA; however, protection of DSCG/REP was more pronounced than that of MON. This difference was statistically significant even if the data were adjusted for the increase in FEV1 between inhalation of DSCG/REP and challenge (DSCG/REP(adjusted). The nadir FEV1 level after exercise following prophylaxis with DSCG/REP was even higher than the pre-inhalation FEV1 value. From these data, protection indices of 66%, 81%, and 113% for MON, DSCG/REP(adjusted), and DSCG/REP(unadjusted), respectively, were estimated.CONCLUSIONS:
Inhalation of DSCG/REP before exercise provides significantly better protection against EIA than three days treatment with MON.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Metaproterenol
/
Quinolines
/
Asthma, Exercise-Induced
/
Theophylline
/
Bronchodilator Agents
/
Cromolyn Sodium
/
Anti-Asthmatic Agents
/
Acetates
Type of study:
Clinical_trials
Limits:
Adolescent
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Arzneimittelforschung
Year:
2008
Document type:
Article
Affiliation country:
Germany