Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity.
Bioorg Med Chem Lett
; 18(17): 4868-71, 2008 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-18678487
ABSTRACT
C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 microg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triazoles
/
Oxazolidinones
/
Anti-Bacterial Agents
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2008
Document type:
Article
Affiliation country:
United States