Enhancement of hypoxia-induced apoptosis of human breast cancer cells via STAT5b by momilactone B.

Joung, Youn-Hee; Lim, Eun-Joung; Kim, Mi-Sun; Lim, So Dug; Yoon, So-Young; Lim, Young Chang; Yoo, Young Bum; Ye, Sang-Kyu; Park, Taekyu; Chung, Ill-Min; Bae, Ki-Yeol; Yang, Young Mok

Joung, Youn-Hee; Lim, Eun-Joung; Kim, Mi-Sun; Lim, So Dug; Yoon, So-Young; Lim, Young Chang; Yoo, Young Bum; Ye, Sang-Kyu; Park, Taekyu; Chung, Ill-Min; Bae, Ki-Yeol; Yang, Young Mok.

Affiliation

Joung YH; Department of Pathology, School of Medicine, and Bio-Food and Drug Research Center, Konkuk University, Chungju City 380-701, Korea.

Int J Oncol ; 33(3): 477-84, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18695876

Subject(s)

Apoptosis/drug effects; Breast Neoplasms/pathology; Cell Hypoxia/drug effects; Diterpenes/pharmacology; Lactones/pharmacology; STAT5 Transcription Factor/drug effects; Blotting, Western; Breast Neoplasms/metabolism; Cell Hypoxia/physiology; Cell Line, Tumor; Cell Proliferation/drug effects; Cyclin D1/drug effects; Cyclin D1/metabolism; Cyclin-Dependent Kinase 4/drug effects; Cyclin-Dependent Kinase 4/metabolism; Cyclin-Dependent Kinase Inhibitor p21/drug effects; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Electrophoretic Mobility Shift Assay; Female; Flow Cytometry; Gene Expression/drug effects; Humans; Proto-Oncogene Proteins c-bcl-2/drug effects; Proto-Oncogene Proteins c-bcl-2/metabolism; RNA, Small Interfering; STAT5 Transcription Factor/metabolism; bcl-2-Associated X Protein/drug effects; bcl-2-Associated X Protein/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Cell Hypoxia / Apoptosis / Diterpenes / STAT5 Transcription Factor / Lactones Limits: Female / Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2008 Document type: Article Country of publication: Greece

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