Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.

Proost, Paul; Loos, Tamara; Mortier, Anneleen; Schutyser, Evemie; Gouwy, Mieke; Noppen, Samuel; Dillen, Chris; Ronsse, Isabelle; Conings, René; Struyf, Sofie; Opdenakker, Ghislain; Maudgal, Prabhat C; Van Damme, Jo

Proost, Paul; Loos, Tamara; Mortier, Anneleen; Schutyser, Evemie; Gouwy, Mieke; Noppen, Samuel; Dillen, Chris; Ronsse, Isabelle; Conings, René; Struyf, Sofie; Opdenakker, Ghislain; Maudgal, Prabhat C; Van Damme, Jo.

Affiliation

Proost P; Laboratory of Molecular Immunology, Rega Institute, K.U.Leuven, Leuven, Belgium. paul.proost@rega.kuleuven.be

J Exp Med ; 205(9): 2085-97, 2008 Sep 01.

Article in En | MEDLINE | ID: mdl-18710930

Subject(s)

Citrulline/chemistry; Hydrolases/metabolism; Interleukin-8/metabolism; Animals; Arginine; Autoimmune Diseases; Cornea/metabolism; Glycosylation; Humans; Inflammation; Neovascularization, Physiologic; Phosphorylation; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Rabbits

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-8 / Citrulline / Hydrolases Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2008 Document type: Article Affiliation country: Belgium Country of publication: United States

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