A novel toxin-antitoxin operon talA/B from the Gram-positive bacterium Leifsonia xyli subsp. cynodontis.
FEBS Lett
; 582(21-22): 3211-6, 2008 Sep 22.
Article
in En
| MEDLINE
| ID: mdl-18722371
ABSTRACT
Here we report a toxin-antitoxin (TA) operon talAB identified from the Gram-positive bacterium Leifsonia xyli subsp. cynodontis. It is shown that talB encodes a broad-host cytotoxin functioning in different Gram-positive bacteria, while talA encodes its antidote. TalA and TalB form different hetero-oligomers in vitro; these hetero-oligomers, but not the antitoxin TalA, strongly bind to the talAB promoter region containing two inverted repeats. This represents a new mechanism of binding the promoter of a TA operon by the toxin and antitoxin complexes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Operon
/
Bacterial Toxins
/
Actinomycetales
/
Antitoxins
/
Gene Expression Regulation, Bacterial
Language:
En
Journal:
FEBS Lett
Year:
2008
Document type:
Article
Affiliation country:
China