A nanosized, thermo-sensitive drug carrier: self-assembled Fe(3)O(4)-OA-g-P(OA-co-NIPAAm) magnetomicelles.
J Biomater Sci Polym Ed
; 19(9): 1249-59, 2008.
Article
in En
| MEDLINE
| ID: mdl-18727864
ABSTRACT
Novel thermo-sensitive magnetomicelles that consist of a magnetic core, Fe(3)O(4)-oleic acid (Fe(3)O(4)-OA), and an amphiphilic surface layer of thermo-sensitive poly(oleic acid-co-N-isopropylacrylamide) P(OA-co-NIPAAm) co-polymer were prepared. Fe(3)O(4) magnetic cores functionalized with double bonds of oleic acid were prepared by suspension-oxidation reaction. Subsequently, by the co-polymerization of hydrophilic NIPAAm, hydrophobic OA and the Fe(3)O(4)-OA magnetic core, the thermo-sensitive amphiphilic polymers (P(OA-co-NIPAAm)) were grafted to obtain Fe(3)O(4)-OA-g-P(OA-co-NIPAAm) nanoparticles. The surface polymeric layer of Fe(3)O(4)-OA-g-P(OA-co-NIPAAm) nanoparticles would self-assemble in aqueous media to form a micellar structure attributed to the amphiphilic P(OA-co-NIPAAm) polymers. The model drug, prednisone acetate, was loaded in the magnetomicelles and in vitro release behavior of loaded drug in magnetomicelles was further investigated, which showed a thermo-sensitive release behavior due to the thermo-sensitive structural changes of the micellar surface layer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymers
/
Temperature
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Drug Carriers
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Ferrosoferric Oxide
/
Nanoparticles
Type of study:
Diagnostic_studies
Language:
En
Journal:
J Biomater Sci Polym Ed
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2008
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
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GREAT BRITAIN
/
INGLATERRA
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REINO UNIDO
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SCOTLAND
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UK
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UNITED KINGDOM