Accumulation of hypoxia-inducible factor-1 alpha protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid.

Zhang, Jing; Song, Li-Ping; Huang, Ying; Zhao, Qian; Zhao, Ke-Wen; Chen, Guo-Qiang

Zhang, Jing; Song, Li-Ping; Huang, Ying; Zhao, Qian; Zhao, Ke-Wen; Chen, Guo-Qiang.

Affiliation

Zhang J; Institute of Health Science, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences (SIBS)-Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, China.

Haematologica ; 93(10): 1480-7, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18728026

Subject(s)

Cell Differentiation/drug effects; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Leukemia, Myeloid/metabolism; Leukemia, Myeloid/pathology; Tretinoin/pharmacology; CCAAT-Enhancer-Binding Protein-alpha/metabolism; Cell Line, Tumor; Copper/pharmacology; Core Binding Factor Alpha 2 Subunit/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/genetics; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Leukemia, Myeloid/genetics; Proto-Oncogene Proteins/metabolism; RNA Interference; RNA, Messenger/genetics; Trans-Activators/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tretinoin / Leukemia, Myeloid / Cell Differentiation / Hypoxia-Inducible Factor 1, alpha Subunit Limits: Humans Language: En Journal: Haematologica Year: 2008 Document type: Article Affiliation country: China

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