The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40 is lowered by ultra-endurance exercise in athletes.
Br J Sports Med
; 45(1): 42-5, 2011 Jan.
Article
in En
| MEDLINE
| ID: mdl-18728056
ABSTRACT
BACKGROUND:
Soluble CD40 ligand (sCD40L) is a powerful marker of cardiovascular risk. Exercise is known to decrease cardiovascular risk, but the impact of ultra-endurance exercise on sCD40L responses is unknown.OBJECTIVE:
To examine the relationship between ultra-endurance exercise in trained athletes and levels of sCD40L and its natural ligand sCD40.DESIGN:
Control-trial, crossover design, exercise intervention study of sCD40L and sCD40 levels.SETTING:
Outdoor exercise and laboratory testing, single centre study, School of Physical Education, University of Otago, New Zealand.PARTICIPANTS:
Nine trained ultra-endurance athletes.INTERVENTIONS:
Athletes exercised (cycled and jogged) for 17 of 24 h. Venous blood was sampled at baseline and serially throughout exercise and 24 and 48 h after exercise. The athletes completed a 24 h control trial on a separate occasion, in randomised order. MAIN OUTCOME MEASUREMENTS Mean levels of sCD40L and sCD40 during exercise and rest with 95% CIs.RESULTS:
sCD40L levels dropped steadily from baseline (median 4128 pg/ml) to a measured nadir at 24 h following exercise (median 1409 pg/ml) (p=0.01). The levels had started to rise again by 48 h after exercise. When measured as a group, sCD40L levels remained constant during a control rest period. sCD40 levels remained constant on both exercise and control days.CONCLUSION:
Ultra-endurance exercise lowers the levels of the cardiovascular risk marker sCD40L in athletes. These results raise the possibility that exercise-induced changes in sCD40L may provide one of the mechanisms by which exercise lowers cardiovascular risk.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sports
/
Cardiovascular Diseases
/
Exercise
/
CD40 Ligand
Type of study:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Br J Sports Med
Year:
2011
Document type:
Article
Affiliation country:
New Zealand