Inhibition of human immunodeficiency virus-1 entry using vectors expressing a multimeric hammerhead ribozyme targeting the CCR5 mRNA.

Nazari, Reza; Ma, Xue Zhong; Joshi, Sadhna

Nazari, Reza; Ma, Xue Zhong; Joshi, Sadhna.

Affiliation

Nazari R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3E2, Canada.
Ma XZ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3E2, Canada.
Joshi S; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E2, Canada.

J Gen Virol ; 89(Pt 9): 2252-2261, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18753234

Subject(s)

HIV-1/genetics; HIV-1/physiology; RNA, Catalytic/genetics; RNA, Catalytic/metabolism; Receptors, CCR5/genetics; Animals; Base Sequence; CD4-Positive T-Lymphocytes/enzymology; CD4-Positive T-Lymphocytes/virology; Cell Line; DNA, Viral/genetics; DNA, Viral/metabolism; Gene Expression; Genes, Viral; Genetic Vectors; Humans; Mice; Molecular Sequence Data; RNA, Messenger/genetics; RNA, Viral/genetics; Transduction, Genetic; Virus Internalization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Catalytic / HIV-1 / Receptors, CCR5 Limits: Animals / Humans Language: En Journal: J Gen Virol Year: 2008 Document type: Article Affiliation country: Canada

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