Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.

Moro, Tadashi; Shimoyama, Yoshihito; Kushida, Miwa; Hong, Yun Yu; Nakao, Sachie; Higashiyama, Reiichi; Sugioka, Yoshihiko; Inoue, Hideo; Okazaki, Isao; Inagaki, Yutaka

Moro, Tadashi; Shimoyama, Yoshihito; Kushida, Miwa; Hong, Yun Yu; Nakao, Sachie; Higashiyama, Reiichi; Sugioka, Yoshihiko; Inoue, Hideo; Okazaki, Isao; Inagaki, Yutaka.

Affiliation

Moro T; Tokai University School of Medicine, 143 Shimo-kasuya, Isehara, Kanagawa 259-1193, Japan.

Life Sci ; 83(15-16): 531-9, 2008 Oct 10.

Article in En | MEDLINE | ID: mdl-18771671

Subject(s)

Anti-Inflammatory Agents/pharmacology; Collagen Type I/genetics; Glycyrrhizic Acid/pharmacology; Liver Cirrhosis/prevention & control; Smad3 Protein/antagonists & inhibitors; Animals; Anti-Inflammatory Agents/metabolism; Blotting, Western; Carbon Tetrachloride Poisoning/pathology; Carbon Tetrachloride Poisoning/prevention & control; Carcinoma, Hepatocellular/prevention & control; Cells, Cultured; Fluorescent Antibody Technique; Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism; Glycyrrhizic Acid/metabolism; Humans; Indicators and Reagents; Luciferases/metabolism; Mice; Mitogen-Activated Protein Kinases/metabolism; Mutant Chimeric Proteins/metabolism; Promoter Regions, Genetic/drug effects; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/drug effects; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycyrrhizic Acid / Collagen Type I / Smad3 Protein / Liver Cirrhosis / Anti-Inflammatory Agents Limits: Animals / Humans Language: En Journal: Life Sci Year: 2008 Document type: Article Affiliation country: Japan Country of publication: Netherlands

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