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A new family of small (4kDa) neurotoxins from the venoms of spiders of the genus Phoneutria.
Lúcio, A D; Campos, F V; Richardson, M; Cordeiro, M N; Mazzoni, M S C; de Lima, M E; Pimenta, M C; Bemquerer, M P; Figueiredo, S G; Gomes, P C; Beirão, P S L.
Affiliation
  • Lúcio AD; Dept. of Biochemistry and Immunology; Instituto de Ciências Biológicas, Brazil.
Protein Pept Lett ; 15(7): 700-8, 2008.
Article in En | MEDLINE | ID: mdl-18782065
ABSTRACT
A family of 4kDa neurotoxic peptides was purified from venoms of Phoneutria spiders. All have six cysteine residues, and low similarity with other neurotoxins. Three toxins caused moderate inhibition of L-type Ca(2+) channels. The structure of toxin PRTx27C3 was modeled and compared with toxin ADO1. The importance of four residues is suggested.
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Collection: 01-internacional Database: MEDLINE Main subject: Spider Venoms / Spiders / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Protein Pept Lett Journal subject: BIOQUIMICA Year: 2008 Document type: Article Affiliation country: Brazil
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Spider Venoms / Spiders / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Protein Pept Lett Journal subject: BIOQUIMICA Year: 2008 Document type: Article Affiliation country: Brazil