Antimicrobial lipopolypeptides composed of palmitoyl Di- and tricationic peptides: in vitro and in vivo activities, self-assembly to nanostructures, and a plausible mode of action.

Makovitzki, Arik; Baram, Jonathan; Shai, Yechiel

Makovitzki, Arik; Baram, Jonathan; Shai, Yechiel.

Affiliation

Makovitzki A; Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel.

Biochemistry ; 47(40): 10630-6, 2008 Oct 07.

Article in En | MEDLINE | ID: mdl-18783248

Subject(s)

Anti-Infective Agents/chemistry; Palmitic Acid/chemistry; Peptides/chemistry; Animals; Anti-Infective Agents/chemical synthesis; Anti-Infective Agents/pharmacology; Bacteria/drug effects; Bacteria/ultrastructure; Candida albicans/drug effects; Candida albicans/ultrastructure; Cell Membrane/drug effects; Cell Membrane/ultrastructure; Female; Mice; Mice, Nude; Microscopy, Electron, Transmission; Nanostructures/chemistry; Nanostructures/ultrastructure; Peptides/chemical synthesis; Peptides/pharmacology; Phosphatidylethanolamines/chemistry; Polylysine/analogs & derivatives; Polylysine/chemistry; Skin/cytology; Skin/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Palmitic Acid / Anti-Infective Agents Limits: Animals Language: En Journal: Biochemistry Year: 2008 Document type: Article

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