High-throughput screening identifies cardiac glycosides as potent inhibitors of human tissue kallikrein expression: implications for cancer therapies.

Prassas, Ioannis; Paliouras, Miltiadis; Datti, Alessandro; Diamandis, Eleftherios P

Prassas, Ioannis; Paliouras, Miltiadis; Datti, Alessandro; Diamandis, Eleftherios P.

Affiliation

Prassas I; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Clin Cancer Res ; 14(18): 5778-84, 2008 Sep 15.

Article in En | MEDLINE | ID: mdl-18794087

Subject(s)

Breast Neoplasms/metabolism; Cardiac Glycosides/pharmacology; Tissue Kallikreins/antagonists & inhibitors; Antineoplastic Agents/pharmacology; Breast Neoplasms/genetics; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Gene Library; Humans; Proto-Oncogene Mas; Transcription, Genetic/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Cardiac Glycosides / Tissue Kallikreins Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2008 Document type: Article Affiliation country: Canada Country of publication: United States

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