Angiotensinogen M235T associated with mitral valve prolapse in young Han Chinese male.

ABSTRACT

BACKGROUND: A potential role for the renin-angiotensin system (RAS) in mitral valve prolapse (MVP) has been reported. The RAS genes are good candidates for evaluating the association with MVP. The angiotensinogen (AGT) gene has an important role in RAS and was shown to be related to MVP. However, no study on the association of AGT M235T in men with MVP has been reported. In this article, we investigated the potential role of AGT M235T polymorphism in men with MVP. METHODS: Seventy-one unrelated study subjects with MVP, 236 control subjects (matched with respect to age and sex), and 178 community subjects from southern Taiwan were included in this study. All participants were male Han Chinese population. All cases fulfilled the criteria of MVP and the new echocardiographic criteria for MVP. The AGT M235T polymorphism was detected by polymerase chain reaction-restricted fragment length polymorphism. RESULTS: There was a statistically significant difference in the M235 allelic frequency between MVP study subjects and control subjects (chi = 4.390; P = 0.036). The chi test for trend also showed that the MM genotype frequency had a statistically significant increase with MVP study subjects (chi = 4.339; P = 0.037). CONCLUSIONS: The results suggest a significant association between MM genotype of AGT M235T polymorphism and MVP in men. Therefore, this study indirectly supports the idea that the polymorphism of AGT M235T should be considered when interpreting and designing genetic studies which underlie differences in blood pressure.