Guanosine improves motor behavior, reduces apoptosis, and stimulates neurogenesis in rats with parkinsonism.

Su, Caixin; Elfeki, Nada; Ballerini, Patrizia; D'Alimonte, Iolanda; Bau, Christian; Ciccarelli, Renata; Caciagli, Francesco; Gabriele, Joseph; Jiang, Shucui

Su, Caixin; Elfeki, Nada; Ballerini, Patrizia; D'Alimonte, Iolanda; Bau, Christian; Ciccarelli, Renata; Caciagli, Francesco; Gabriele, Joseph; Jiang, Shucui.

Affiliation

Su C; Department of Surgery (Neurosurgery, Neurobiology), McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada.

J Neurosci Res ; 87(3): 617-25, 2009 Feb 15.

Article in En | MEDLINE | ID: mdl-18816792

Subject(s)

Apoptosis/drug effects; Guanosine/therapeutic use; Motor Activity/drug effects; Neurogenesis/drug effects; Parkinsonian Disorders/drug therapy; Animals; Bromodeoxyuridine; Dopamine/metabolism; Fibroblast Growth Factor 2/metabolism; Intermediate Filament Proteins/metabolism; Male; Nerve Tissue Proteins/metabolism; Nestin; Neurons/drug effects; Neurons/metabolism; Neuroprotective Agents/therapeutic use; Parkinsonian Disorders/chemically induced; Parkinsonian Disorders/physiopathology; Rats; Rats, Sprague-Dawley; Substantia Nigra/drug effects; Substantia Nigra/metabolism; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Parkinsonian Disorders / Neurogenesis / Guanosine / Motor Activity Limits: Animals Language: En Journal: J Neurosci Res Year: 2009 Document type: Article Affiliation country: Canada Country of publication: United States

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