Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans.

Perera, M A; Thirumaran, R K; Cox, N J; Hanauer, S; Das, S; Brimer-Cline, C; Lamba, V; Schuetz, E G; Ratain, M J; Di Rienzo, A

Perera, M A; Thirumaran, R K; Cox, N J; Hanauer, S; Das, S; Brimer-Cline, C; Lamba, V; Schuetz, E G; Ratain, M J; Di Rienzo, A.

Affiliation

Perera MA; Committee on Clinical Pharmacology and Pharmacogenomics, Division of Biological Sciences, University of Chicago, Chicago, IL, USA. mperera@bsd.uchicago.edu

Pharmacogenomics J ; 9(1): 49-60, 2009 Feb.

Article in En | MEDLINE | ID: mdl-18825162

Subject(s)

Black or African American/genetics; Cytochrome P-450 CYP3A/genetics; Haplotypes; Polymorphism, Single Nucleotide; Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Cytochrome P-450 CYP3A/metabolism; Female; Gene Frequency; Humans; Linkage Disequilibrium; Male; Midazolam/pharmacokinetics; Middle Aged; Predictive Value of Tests; Transfection; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Black or African American / Haplotypes / Polymorphism, Single Nucleotide / Cytochrome P-450 CYP3A Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Pharmacogenomics J Journal subject: BIOLOGIA MOLECULAR / FARMACOLOGIA Year: 2009 Document type: Article Affiliation country: United States

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