Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury.

Wu, Hongtao; Lu, Dunyue; Jiang, Hao; Xiong, Ye; Qu, Changsheng; Li, Bo; Mahmood, Asim; Zhou, Dong; Chopp, Michael

Wu, Hongtao; Lu, Dunyue; Jiang, Hao; Xiong, Ye; Qu, Changsheng; Li, Bo; Mahmood, Asim; Zhou, Dong; Chopp, Michael.

Affiliation

Wu H; Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.

J Neurosurg ; 109(4): 691-8, 2008 Oct.

Article in En | MEDLINE | ID: mdl-18826357

Subject(s)

Apoptosis/drug effects; Brain Injuries/drug therapy; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Simvastatin/pharmacology; Animals; Brain Injuries/pathology; Cell Survival/drug effects; Forkhead Transcription Factors/metabolism; I-kappa B Proteins/metabolism; In Situ Nick-End Labeling; Male; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Neurons/pathology; Nitric Oxide Synthase Type II/metabolism; Nitric Oxide Synthase Type III; Phosphorylation/drug effects; Rats; Rats, Wistar; Recovery of Function/drug effects; Trauma Severity Indices

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Injuries / Signal Transduction / Apoptosis / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Proto-Oncogene Proteins c-akt Limits: Animals Language: En Journal: J Neurosurg Year: 2008 Document type: Article Affiliation country: United States Country of publication: United States

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