Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells.

Koo, Jin-Suk; Choi, Won-Cheol; Rhee, Yun-Hee; Lee, Hyo-Jeong; Lee, Eun-Ok; Ahn, Kwang Seok; Bae, Hyun-Soo; Ahn, Kyoo-Seok; Kang, Jong-Min; Choi, Sang-Un; Kim, Myung Ok; Lu, Junxuan; Kim, Sung-Hoon

Koo, Jin-Suk; Choi, Won-Cheol; Rhee, Yun-Hee; Lee, Hyo-Jeong; Lee, Eun-Ok; Ahn, Kwang Seok; Bae, Hyun-Soo; Ahn, Kyoo-Seok; Kang, Jong-Min; Choi, Sang-Un; Kim, Myung Ok; Lu, Junxuan; Kim, Sung-Hoon.

Affiliation

Koo JS; Oriental Medical College, Kyunghee University, 1 Hoegidong, Dongdaemungu, Seoul 130-701, South Korea.

Life Sci ; 83(21-22): 700-8, 2008 Nov 21.

Article in En | MEDLINE | ID: mdl-18845169

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents/pharmacology; Cell Cycle/drug effects; Drug Resistance, Multiple/drug effects; Drug Resistance, Neoplasm/drug effects; Paclitaxel/pharmacology; Quinolines/pharmacology; ATP Binding Cassette Transporter, Subfamily B, Member 1/biosynthesis; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Blotting, Western; Cell Line, Tumor; Cell Survival/drug effects; Cytochromes c/metabolism; Drug Synergism; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Microscopy, Confocal; Microscopy, Fluorescence; Rhodamine 123; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Cell Cycle / Paclitaxel / Drug Resistance, Multiple / Drug Resistance, Neoplasm / Antineoplastic Agents / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Life Sci Year: 2008 Document type: Article Affiliation country: South Korea Country of publication: Netherlands

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