Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects.
Curr Opin Pharmacol
; 8(6): 765-76, 2008 Dec.
Article
in En
| MEDLINE
| ID: mdl-18845272
ABSTRACT
Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-coupled receptors which has only very recently been implicated in the regulation of neuroendocrine function. In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary-Adrenal System
/
Annexin A1
/
Receptors, Formyl Peptide
/
Hypothalamo-Hypophyseal System
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Pharmacol
Journal subject:
FARMACOLOGIA
Year:
2008
Document type:
Article
Affiliation country:
United kingdom