PGE2 signal via EP2 receptors evoked by a selective agonist enhances regeneration of injured articular cartilage.

Otsuka, S; Aoyama, T; Furu, M; Ito, K; Jin, Y; Nasu, A; Fukiage, K; Kohno, Y; Maruyama, T; Kanaji, T; Nishiura, A; Sugihara, H; Fujimura, S; Otsuka, T; Nakamura, T; Toguchida, J

Otsuka, S; Aoyama, T; Furu, M; Ito, K; Jin, Y; Nasu, A; Fukiage, K; Kohno, Y; Maruyama, T; Kanaji, T; Nishiura, A; Sugihara, H; Fujimura, S; Otsuka, T; Nakamura, T; Toguchida, J.

Affiliation

Otsuka S; Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.

Osteoarthritis Cartilage ; 17(4): 529-38, 2009 Apr.

Article in En | MEDLINE | ID: mdl-18922704

Subject(s)

Cartilage, Articular/injuries; Dinoprostone/physiology; Receptors, Prostaglandin E/physiology; Regeneration/physiology; Animals; C-Reactive Protein/metabolism; Cartilage, Articular/drug effects; Cartilage, Articular/pathology; Cartilage, Articular/physiology; Cell Proliferation/drug effects; Disease Models, Animal; Drug Evaluation, Preclinical/methods; Matrix Metalloproteinase 3/metabolism; Rabbits; Receptors, Prostaglandin E/agonists; Receptors, Prostaglandin E, EP2 Subtype; Regeneration/drug effects; Reverse Transcriptase Polymerase Chain Reaction/methods; Synovial Fluid/metabolism; Synovial Membrane/drug effects; Synovial Membrane/pathology; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Regeneration / Dinoprostone / Cartilage, Articular / Receptors, Prostaglandin E Type of study: Prognostic_studies Limits: Animals Language: En Journal: Osteoarthritis Cartilage Journal subject: ORTOPEDIA / REUMATOLOGIA Year: 2009 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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