Expression patterns of the lysophospholipid receptor genes during mouse early development.
Dev Dyn
; 237(11): 3280-94, 2008 Nov.
Article
in En
| MEDLINE
| ID: mdl-18924241
ABSTRACT
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sphingosine
/
Lysophospholipids
/
Gene Expression Regulation, Developmental
/
Organogenesis
/
Receptors, Lysophosphatidic Acid
Limits:
Animals
Language:
En
Journal:
Dev Dyn
Journal subject:
ANATOMIA
Year:
2008
Document type:
Article
Affiliation country:
Japan