The use of chemical double-mutant cycles in biomolecular recognition studies: application to HCV NS3 protease inhibitors.

Kawai, Stephen H; Bailey, Murray D; Halmos, Ted; Forgione, Pat; Laplante, Steven R; Llinàs-Brunet, Montse; Naud, Julie; Goudreau, Natalie

Kawai, Stephen H; Bailey, Murray D; Halmos, Ted; Forgione, Pat; Laplante, Steven R; Llinàs-Brunet, Montse; Naud, Julie; Goudreau, Natalie.

Affiliation

Kawai SH; Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100, rue Cunard, Laval, Québec, Canada.

ChemMedChem ; 3(11): 1654-7, 2008 Nov.

Article in En | MEDLINE | ID: mdl-18942693

Subject(s)

Antiviral Agents/pharmacology; Hepacivirus/metabolism; Mutation; Viral Nonstructural Proteins/genetics; Viral Nonstructural Proteins/metabolism; Catalytic Domain; Chemistry, Pharmaceutical/methods; Drug Design; Gene Deletion; Glycine/chemistry; Inhibitory Concentration 50; Molecular Conformation; Peptides/chemistry; Protein Structure, Tertiary; Structure-Activity Relationship; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Viral Nonstructural Proteins / Hepacivirus / Mutation Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2008 Document type: Article Affiliation country: Canada

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