Bilateral inhibition of gamma-aminobutyric acid type A receptor function within the basolateral amygdala blocked propofol-induced amnesia and activity-regulated cytoskeletal protein expression inhibition in the hippocampus.

Ren, Yu; Zhang, Fu-Jun; Xue, Qing-Sheng; Zhao, Xin; Yu, Bu-Wei

Ren, Yu; Zhang, Fu-Jun; Xue, Qing-Sheng; Zhao, Xin; Yu, Bu-Wei.

Affiliation

Ren Y; Department of Anesthesiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China.

Anesthesiology ; 109(5): 775-81, 2008 Nov.

Article in En | MEDLINE | ID: mdl-18946287

Subject(s)

Amnesia/prevention & control; Amygdala/physiology; Cytoskeletal Proteins/biosynthesis; Hippocampus/physiology; Propofol/toxicity; Receptors, GABA-A/physiology; Amnesia/chemically induced; Amnesia/physiopathology; Amygdala/drug effects; Animals; Bicuculline/pharmacology; Cytoskeletal Proteins/antagonists & inhibitors; Functional Laterality/drug effects; Functional Laterality/physiology; GABA-A Receptor Antagonists; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Hippocampus/drug effects; Male; Neural Inhibition/drug effects; Neural Inhibition/physiology; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Propofol / Receptors, GABA-A / Cytoskeletal Proteins / Amnesia / Hippocampus / Amygdala Limits: Animals Language: En Journal: Anesthesiology Year: 2008 Document type: Article Country of publication: United States

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